A young boy carrying apples

24 hour blood pressure monitoring results

* Final gross prices may vary according to local VAT.

Abstract

The aim of this prospective, randomized, open-label, blinded endpoint (PROBE) study was to compare the antihypertensive efficacy of 2 angiotensin II (AII) receptor antagonists with different pharmacologic profiles, valsartan and olmesartan, in patients with mild-to-moderate essential hypertension. After an initial 2-week washout period, 114 patients (64 men, 50 women; aged 35–70 years) were randomly assigned to receive valsartan 160 mg or olmesartan 20 mg once daily for 8 weeks. After the washout period and after 2 and 8 weeks of treatment, 24-hour ambulatory blood pressure monitoring (ABPM) was performed using a noninvasive device, and casual blood pressure (BP) and heart rate were measured. Both olmesartan and valsartan had a clear-cut antihypertensive effect. However, significantly earlier and more pronounced antihypertensive activity was achieved with valsartan than with olmesartan, as demonstrated by (1) significantly lower 24-hour, daytime, and nighttime ABPM values after 2 weeks with valsartan (P < .01); (2) significantly lower percentage of abnormal BP readings with valsartan; (3) significantly higher trough-peak ratio and smoothness index with valsartan, suggesting a more prolonged and homogeneous antihypertensive effect; and (4) lower 24-hour postdose clinic systolic and diastolic BP values versus olmesartan. These findings show that pharmacodynamic and pharmacokinetic differences between All receptor antagonists, at clinically comparable dosages, may be associated with differences in anti hypertensive efficacy.

Keywords

valsartan olmesartan hypertension
Source: link.springer.com
RELATED VIDEO
When Is Low Blood Pressure Too Low?
When Is Low Blood Pressure Too Low?
The Magnesium Solution for High Blood Pressure
The Magnesium Solution for High Blood Pressure
24 hour ECG
24 hour ECG
RELATED FACTS
Share this Post

Related posts

Kinetik Blood pressure monitoring Review

Kinetik Blood pressure monitoring Review

JULY 13, 2024

Kinetik was born from a single idea. That health monitors are not just for people with diagnosed conditions, such as Hypertension…

Read More
Blood pressure monitoring System

Blood pressure monitoring System

JULY 13, 2024

John F Stover, Reto Stocker contributed equally to this work. Background Cardiovascular monitoring is a standard procedure…

Read More